Clinical trial for inappropriate sinus tachycardia IST Dysautonomia POTS ablation or resting heart rate 100 bpm


The HEAL-IST Trial is recruiting participants to evaluate the safety and effectiveness of a hybrid sinus node sparing procedure to treat patients with symptomatic drug refractory or drug intolerant inappropriate sinus tachycardia or IST.

What is Inappropriate Sinus Tachycardia or IST?

IST is a complex heart condition that occurs in otherwise healthy younger people and causes rapid heart rates of over 100 bpm, even at rest.

Common symptoms of inappropriate sinus tachycardia include:

  • Palpitations - fluttering or pounding sensations in your chest
  • Chest discomfort 
  • Weakness or dizziness 
  • Lightheadedness or fainting 
  • Shortness of breath 
  • Fatigue 
  • Anxiety 
  • Exaggerated response to exercise or stress

These symptoms can affect day-to-day activities and can diminish one’s quality of life. There are currently no FDA-approved therapies to treat inappropriate sinus tachycardia. However, a hybrid sinus node sparing ablation is being studied as a potential new treatment option for patients who suffer from symptomatic, drug-resistant or intolerant IST.


How POTS Differs from IST

Postural Orthostatic Tachycardia Syndrome (POTS) is another type of heart condition. Although patients with POTS can experience similar symptoms to inappropriate sinus tachycardia like lightheadedness, shortness of breath, fatigue and anxiety, a key difference between POTS and IST is resting heart rate. Individuals with POTS typically have a resting heart rate of 90 bpm or less, whereas those with IST have a resting heart rate usually greater than 100 bpm.

Dr. Rani Kronenberger (University Hospital, Brussels, Belgium) describes key differences between IST and POTS and introduces the hybrid ablation procedure to treat IST.

Are you a candidate for the HEAL-IST Trial?

To be considered for the HEAL-IST Trial:

  • You are between 18 and 75 years of age
  • You have already been diagnosed with inappropriate sinus tachycardia
  • You are willing and able to receive all the trial-related procedures and go to the scheduled follow-up visits over a 2-year period of time
  • You are willing to provide written informed consent for the trial

Your trial doctor or research staff will determine if you qualify for the HEAL-IST Trial. Click Here for the Patient Information Guide. 

What is the Hybrid Ablation Procedure?

A novel sinus node sparing procedure is being evaluated in the HEAL-IST Trial. Designed to spare the sinoatrial node, the heart’s natural pacemaker, this procedure involves creating lesions along certain areas of the heart’s outside surface and sometimes inside the heart with the goal of lowering the rapid heart rate responsible for IST.

Hospital Centers That Are Currently Recruiting Participants

US Sites/Hospital State City
Sequoia Hospital California Redwood City
Stanford University Hospital California Redwood City
Sarasota Memorial Hospital Florida Sarasota
University of Florida Florida Gainesville
St Joseph's Bay Care Hospital Florida Tampa
Baptist Health Florida Miami
Memorial Health Georgia Savannah
Saint Alphonsus Hospital Idaho Boise
Kansas City Cardiac Arrhythmia Research Kansas Overland Park
Mayo Clinic Minnesota Rochester
Wake Forest University Health Sciences North Carolina Winston-Salem
Christ Hospital Ohio Cincinnati
TriHealth Ohio Cincinnati
Texas Cardiac Arrhythmia Research Foundation Texas Austin
Intermountain Medical Center Utah Salt Lake City
Virginia Commonwealth University Hospital Virginia Richmond
Swedish Hospital Washington Seattle
Medstar Washington Hospital Center Washington District of Columbia NA
International Sites Country City
UZ Brussels Belgium Brussels
Maastricht University Medical Center The Netherlands Maastricht
Northern General Hospital England Sheffield

Physician Videos

Why Are You Passionate About Treating IST?

Drs. Chad R Brodt, Gaurang D. Gandhi, Anson M Lee, and Thomas M Beaver discuss why they are passionate about treating patients with symptomatic inappropriate sinus tachycardia.

Treatment Options for IST

Drs. Chad R. Brodt, Anson M. Lee and Thomas M Beaver provide a historical perspective on treating inappropriate sinus tachycardia as well as discuss a new hybrid therapy approach and collaborative care for managing patients with IST.

Thomas M. Beaver, MD, MPH

Dr. Beaver discusses the impact to quality of life in patients suffering from symptomatic inappropriate sinus tachycardia as well as treatment options and an overview of the hybrid ablation procedure.

Mark La Meir, MD, PhD

Professor La Meir describes typical symptoms of inappropriate sinus tachycardia, the hybrid ablation procedure and what it means to have a hybrid team approach for the treatment of IST.

DJ Lakkireddy, MD

Hear how Dr. Dhanunjaya (DJ) Lakkireddy describes patients who suffer from inappropriate sinus tachycardia and what medications have been used to treat symptoms of IST.

Carlo de Asmundis, MD, PhD

Professor de Asmundis walks through common symptoms of inappropriate sinus tachycardia and the hybrid team approach for the treatment of IST.

Key Publications